Using computational fluid dynamics to simulate PeptiInks® extrusion
It is widely established that Covid-19 has had an unprecedented impact on scientific research. For almost all there has been a dramatic shift in the way we are approaching our work. This has not only involved a transition to virtual meetings, conferences and online communication, but for many PhD students it has also involved a shift in project emphasis. In particular lockdown has seen a rise in review papers being written, results analysed leading to papers published and often the transition to added computational analysis.
We decided to look at what one of our CASE-award PhD students, Patricia Santos, has been doing during the lockdown. Patricia is based at University College London (UCL) under the supervision of Dr. Deepak Kalaskar and her work is focussed on 3D bioprinting tissues using
animal-free peptide-based bioinks; PeptiInks®. She started her research by trying to understand the forces that arise during the printing process in an extrusion-based 3D bioprinter. These forces are vital factors responsible for regulating cell survival during cell-laden bioprinting process.
We recently interviewed her on her lockdown work experience, and this is what she said…
“Using computational fluid dynamics, I have developed with the use of ANSYS Fluent software, a model by which the extrusion of different materials such as PeptiInks® can be simulated using various printing head sizes and extrusion pressures. The materials extruded are characterised by rheology and the printing head sizes and pressures can be changed to model different scenarios. The aim of the simulations is to find the optimal parameter combination that produces the lowest shear stress forces, maximising cell survivability”
Further information on this work will be presented at the 6th Annual Surgery Virtual Meeting, 5th – 9th October, 2020. Further details of the programme can be found here. To learn more about Manchester BIOGEL’s PeptiInks® and our collaborative opportunities, please get in touch.