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3D Cell Culture : “Current Challenges and Future Opportunities for Organoid Culture”

Panel Discussion Podcast

Our first Panel Discussion in the series brings together both academic and industrial professionals from across the international 3D cell culture community to discuss and explore the current challenges and opportunities faced within this field of research, and their predictions for what its future holds.

Listen to the Panel Discussion Podcast!

Explored Themes:

  • Discussing the key drivers for switching from 2D to 3D cell culture and the challenges and opportunities faced.
  • Why organoids are attracting so much attention in cell culture.
  • Characteristics to look for in a biomaterial and which are best the culture of organoids.
  • The future direction of 3D cell culture, discussing more importantly whether there will be a time animal use and testing can be eliminated from drug discovery

Let’s Meet the Panel:

Dr. Salvatore Simmini
Senior Scientist in R&D at STEMCELL Technologies Ltd. 

Dr. Salvatore Simmini is a Senior Scientist in the Research and Development Department at STEMCELL Technologies Ltd., Cambridge, UK. He currently leads a team actively working in developing innovative products for culturing gastrointestinal and lung organoids derived from both pluripotent stem cells (PSCs) and primary tissues. Dr. Simmini also serves as an instructor in several of STEMCELL Technologies’ Pluripotent Stem Cell and Organoids training courses. He received his PhD on Stem Cells, Developmental Biology and Cancer at the University of Utrecht.

Dr. Natasha Lewis
Biomaterials Scientist at Cell Guidance Systems

Dr. Natasha Lewis is a Biomaterials Scientist and KTP Associate working with the University of Glasgow and Cell Guidance Systems to develop biomaterials products incorporating PODS® (Polyhedrin Delivery System) growth factors. She completed her PhD in tissue engineering in Glasgow in 2017, followed by a postdoctoral position at the University of Cambridge and an industrial research role at Enplas. Her current projects involve combining PODS® crystals into a variety of biomaterials for multiple applications, including organoids.  

Prof. Chris Goldring
Chair of Molecular and Cellular Pharmacology  at University of Liverpool

Professor Chris Goldring has more than twenty years of experience of molecular bioanalysis, working with cell culture, in vitro and in vivo models, particularly looking at how the liver responds to pharmaceutical compounds He leads the molecular and cellular toxicology group within the Centre for Drug Safety Science (CDSS), a UK centre based at the University of Liverpool, with a critical mass of scientists studying mechanisms of adverse reactions to therapeutics.  He is also academic coordinator of the Industry-Academic Innovative Medicines Initiative project TransQST (2017-2022).

Jessica Pinheiro de Lucena-Thomas
Bioprocess Engineer at Cellesce

As a Marie Curie FIRE fellow in the Centre for Sustainable and Circular Technologies (CSCT) and with industrial partnership with Cellesce Ltd, she developed in her PhD a bioreactor to culture large quantities of colorectal cancer organoids more efficiently than static cultures for drug discovery applications. She recently joined Cellesce as a Bioprocess Engineer, continuing her work on the development of the company’s next generation bioprocess, that will upscale patient derived organoid production to facilitate their use in high-throughput screening. She submitted her PhD thesis for examination in March 2021.

Dr. Adedamola (Dammy) Olayanju
Principal Scientist at Manchester BIOGEL

Dr. Adedamola (Dammy) Olayanju is the Principal Scientist at Manchester BIOGEL. As the company’s technical expert, his work focuses on the development and application of fully defined synthetic peptide hydrogels in regenerative medicine, tissue engineering and robust in vitro 3D platforms such as the organoid technology for drug screening and development. Prior to joining Manchester BIOGEL, he gained postdoctoral training and his PhD in Pharmacology and Therapeutics at the University of Liverpool.

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