A study by Dr. Angela Imere and her group at the University of Manchester highlighted the support of PeptiGel® Alpha4 in the development of a bilayer membrane to act as anti-adhesion system, aiding restoration of tendon function. This shows that our fully-defined peptide-based hydrogels can support good lubrication properties, 3-dimensional (3D) growth and maintenance of rabbit synoviocytes evidenced with the production of specific matrix components such as hyaluronic acid.
Dr. Clough's paper highlights how PeptiGel® can be used to successfully mimic the 3D tumour microenvironment of breast cancer in vitro. PeptiGel® Alpha 1 was able to closely mimic the mechanical properties of breast tumour tissue and supported the viability and growth of breast cancer cell lines MCF-7 and MDA-MB-231 for 14 days. In addition to this, key features of solid tumors such as hypoxia and invasion were recapitulated.
Dr Armando Del Rio Hernandez’s research group (Imperial College London) used PeptiGels® to mimic the mechanical and chemical environment of both healthy and cancer tissue. Results showed the tumour mimicking PeptiGel® (stiff and acidic) to induce a biomechanical response in PDAC suit-2 cells, resulting in an increased proliferation (expression of Ki67).
In partnership with Promega UK, our Principal Scientist, Dr. Dammy Olayanju, demonstrates how to use hydrogels for organoid and cancer studies to better simulate tissue microenvironments, along with how to validate cell-based assays in 3D microtissues to ensure accurate results. Watch the webinar on-demand to find out more!
This panel discussion offers the exciting opportunity to listen to the experts’ first-hand experiences as to why they believe bioprinting is becoming so popular, the challenges they have faced, and their thoughts on the direction of its future.