Induced pluripotent stem cell derived kidney organoids offer valuable insights into how the organ develops in the body. However, a gap remains in the understanding surrounding the optimal conditions required for the generation of kidney organoids that fully mimics the in vivo organ.

PeptiGel^® and its tuneable properties offers an ideal environment in which the organoid is developing to be optimised. This has allowed Niall Treacy (UCD Conway Institute of Biomolecular and Biomedical Research) to successfully grow kidney organoids in an animal-free synthetic environment.

By bridging the gap in the understanding of the optimal conditions for organoid growth, PeptiGels^® offer an increased understanding of kidney organoid in-vitro modelling for toxicity testing and drug discovery.

Offering a synthetic and animal-free solution, Dr. Dammy Olayanju (Northwick Park Institute for Medical Research) applied PeptiGels^® to provide a disease-free ECM which successfully supported growth of fully formed liver/gastro-intestinal organoids for up to 27 days.

The successful growth of these organoids allowed for reproducible and scalable results to be achieved, opening the potential for PeptiGels^® to provide more reliable preclinical studies for the pharmacological and toxicology studies.

PeptiGel^®  Alpha 4

PeptiGels^® are supplied ready-to-use, animal free and chemically defined with no batch-to-batch variability, giving you reliable and reproducible results whilst saving both time and resource.